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Index > Protein center > PTGS1(Gene name) > Human
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  • PTGS1 (Gene name),
  • Prostaglandin G/H synthase 1 (Protein name ),  PGH1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    PTGS1(COX1);
    Protein name:
    Prostaglandin G/H synthase 1;
    Alternative:
    Prostaglandin H2 synthase 1(PGH synthase 1;PGHS-1;PHS 1);Cyclooxygenase-1(COX-1);Prostaglandin-endoperoxide synthase 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells.
    Subcellular Location:
    Microsome membrane Peripheral membrane protein Endoplasmic reticulum membrane Peripheral membrane protein
    Protein Attributes:
    Sequence length:
    599
    Sequence:
    50:
    MSRSLLLWFL | LFLLLLPPLP | VLLADPGAPT | PVNPCCYYPC | QHQGICVRFG | 
    100:
    LDRYQCDCTR | TGYSGPNCTI | PGLWTWLRNS | LRPSPSFTHF | LLTHGRWFWE | 
    150:
    FVNATFIREM | LMRLVLTVRS | NLIPSPPTYN | SAHDYISWES | FSNVSYYTRI | 
    200:
    LPSVPKDCPT | PMGTKGKKQL | PDAQLLARRF | LLRRKFIPDP | QGTNLMFAFF | 
    250:
    AQHFTHQFFK | TSGKMGPGFT | KALGHGVDLG | HIYGDNLERQ | YQLRLFKDGK | 
    300:
    LKYQVLDGEM | YPPSVEEAPV | LMHYPRGIPP | QSQMAVGQEV | FGLLPGLMLY | 
    350:
    ATLWLREHNR | VCDLLKAEHP | TWGDEQLFQT | TRLILIGETI | KIVIEEYVQQ | 
    400:
    LSGYFLQLKF | DPELLFGVQF | QYRNRIAMEF | NHLYHWHPLM | PDSFKVGSQE | 
    450:
    YSYEQFLFNT | SMLVDYGVEA | LVDAFSRQIA | GRIGGGRNMD | HHILHVAVDV | 
    500:
    IRESREMRLQ | PFNEYRKRFG | MKPYTSFQEL | VGEKEMAAEL | EELYGDIDAL | 
    550:
    EFYPGLLLEK | CHPNSIFGES | MIEIGAPFSL | KGLLGNPICS | PEYWKPSTFG | 
    599:
    GEVGFNIVKT | ATLKKLVCLN | TKTCPYVSFR | VPDASQDDGP | AVERPSTEL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    String:
    KEGG:
    UniGene:
    MIM:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Prostaglandin G/H synthase 1
    Cat.:
    E0122h
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    MSDS:
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    96T
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    ELISA Kit for Human Prostaglandin G/H synthase 1
    Cat.:
    E0122r
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    96T
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    ELISA Kit for Human Prostaglandin G/H synthase 1
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    E0122m
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    96T
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    ELISA Kit for Human Prostaglandin G/H synthase 1
    Cat.:
    E0122b
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    96T
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    ELISA Kit for Human Prostaglandin G/H synthase 1
    MSDS:
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    CLIA Kit for Human Prostaglandin G/H synthase 1
    Cat.:
    U0122b
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Prostaglandin G/H synthase 1
    MSDS:
    Please sign in first.
    CLIA Kit for Human Prostaglandin G/H synthase 1
    Cat.:
    U0122m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Prostaglandin G/H synthase 1
    Cat.:
    U0122r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Prostaglandin G/H synthase 1
    Cat.:
    U0122h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    Polyclonal Antibody for Human Prostaglandin G/H synthase 1
    Polyclonal Antibody for Human Prostaglandin G/H synthase 1
    Cat.:
    P0122Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Prostaglandin G/H synthase 1
    Cat.:
    P0122Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Prostaglandin G/H synthase 1
    Cat.:
    P0122Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Prostaglandin G/H synthase 1
    Monoclonal Antibody for Human Prostaglandin G/H synthase 1
    Monoclonal Antibody for Human Prostaglandin G/H synthase 1
    Monoclonal Antibody for Human Prostaglandin G/H synthase 1
    Monoclonal Antibody for Human Prostaglandin G/H synthase 1
    Monoclonal Antibody for Human Prostaglandin G/H synthase 1
    Protein for Human Prostaglandin G/H synthase 1
    Protein for Human Prostaglandin G/H synthase 1
    Protein for Human Prostaglandin G/H synthase 1
    Protein for Human Prostaglandin G/H synthase 1
    Protein for Human Prostaglandin G/H synthase 1

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    Precision
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    Linearity
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    References
    1. 1.
      "Cloning of human gene encoding prostaglandin endoperoxide synthase and primary structure of the enzyme."
      Yokoyama C. , Tanabe T.
      Biochem. Biophys. Res. Commun.165:888-894(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1);VARIANT ARG-8
    2. 2.
      "Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment."
      Funk C.D. , Funk L.B. , Kennedy M.E. , Pong A.S. , Fitzgerald G.A.
      FASEB J.5:2304-2312(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);MUTAGENESIS OF SER-529;VARIANT ARG-8
    3. 3.
      "Immunoaffinity purification and cDNA cloning of human platelet prostaglandin endoperoxide synthase (cyclooxygenase)."
      Takahashi Y. , Ueda N. , Yoshimoto T. , Yamamoto S. , Yokoyama C. , Miyata A. , Tanabe T. , Fuse I. , Hattori A. , Shibata A.
      Biochem. Biophys. Res. Commun.182:433-438(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ARG-8
      tissue: Platelet.
    4. 4.
      "Alternative splicing of human prostaglandin G/H synthase mRNA and evidence of differential regulation of the resulting transcripts by transforming growth factor beta 1, interleukin 1 beta, and tumor necrosis factor alpha."
      Diaz A. , Reginato A.M. , Jimenez S.A.
      J. Biol. Chem.267:10816-10822(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);VARIANT ARG-8
      tissue: Lung fibroblast.
    5. 5.
      "Cloning, expression, and functional characterization of human cyclooxygenase-1 splicing variants: evidence for intron 1 retention."
      Qin N. , Zhang S.P. , Reitz T.L. , Mei J.M. , Flores C.M.
      J. Pharmacol. Exp. Ther.315:1298-1305(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5 AND 6)
    6. 6.
      "Characterization of the human prostaglandin H synthase 1 gene (PTGS1): exclusion by genetic linkage analysis as a second modifier gene in familial thrombosis."
      Scott B.T. , Hasstedt S.J. , Bovill E.G. , Callas P.W. , Valliere J.E. , Wang L.-H. , Wu K.K. , Long G.L.
      Blood Coagul. Fibrinolysis13:519-531(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1);VARIANTS ARG-8 AND LEU-17
    7. 7.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4);VARIANT ARG-8
      tissue: Caudate nucleus.
      tissue: Hippocampus.
      tissue: Trachea.
    8. 8.
      SeattleSNPs variation discovery resource
      Submitted (2003-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1);VARIANTS ARG-8; LEU-17; HIS-53; LEU-149 AND MET-237
    9. 9.
      "DNA sequence and analysis of human chromosome 9."
      Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
      Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT ARG-8
    11. 11.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ARG-8
      tissue: Brain.
    12. 12.
      "Cyclooxygenases: structural, cellular, and molecular biology."
      Smith W.L. , DeWitt D.L. , Garavito R.M.
      Annu. Rev. Biochem.69:145-182(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION; TISSUE SPECIFICITY AND INHIBITION BY NSAIDS
    13. 13.
      "Aspirin, cyclooxygenase inhibition and colorectal cancer."
      Sostres C. , Gargallo C.J. , Lanas A.
      World J. Gastrointest. Pharmacol. Ther.5:40-49(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION; INHIBITION BY ASPIRIN AND INVOLVEMENT IN COLORECTAL CANCER
    14. 14.
      "Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk."
      Goodman J.E. , Bowman E.D. , Chanock S.J. , Alberg A.J. , Harris C.C.
      Carcinogenesis25:2467-2472(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MET-237 AND ILE-481
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